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Alternative NamesAspartate aminotransferase; Serum glutamic-oxaloacetic transaminase; SGOT
Definition Return to top
AST (aspartate aminotransferase) is an enzyme found in high amounts in heart muscle and liver and skeletal muscle cells. It is also found in lesser amounts in other tissues.
This article discusses the test to measure the amount of AST in the blood.
How the Test is Performed Return to top
Blood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.
Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.
Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.
How the Test Will Feel Return to top
When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the Test is Performed Return to top
This test is mainly done along with other tests (such as ALT, ALP, and bilirubin) to diagnose and monitor liver disease.
Normal Results Return to top
The normal range is 10 to 34 IU/L.
Note: IU/L = international units per liter
What Abnormal Results Mean Return to top
Diseases that affect liver cells increase the levels of AST. However, increased levels of AST alone do not specifically indicate liver disease.
An increase in AST levels may indicate:
Risks Return to top
Other risks associated with having blood drawn are slight but may include:
Considerations Return to top
AST levels may rise during pregnancy and after exercise.
References Return to top
Berk PD, Korenblat KM. Approach to the patient with jaundice or abnormal liver test results. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 150.Update Date: 2/23/2009 Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.