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Alternative Names Return to topBrucella serology; Brucella antibody test or titer
Definition Return to top
Serology for brucellosis is a blood test to look for antibodies against Brucella, the bacteria that causes the disease brucellosis.
How the Test is Performed Return to top
Blood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.
Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.
The blood is then tested in a laboratory to look for antibodies. For Brucella, the serum agglutination test (SAT) is the simplest and most widely used testing method.
How to Prepare for the Test Return to top
There is no special preparation.
How the Test Will Feel Return to top
When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the Test is Performed Return to top
This test may be performed when the doctor suspects brucellosis.
Normal Results Return to top
A normal result shows no antibodies to Brucella. However, during the first few days to weeks of exposure to an antigen, there may be very little antibody production. As brucellosis progresses, more antibodies will be present. If the health care provider suspects brucellosis, you may need to have the test repeated 10 days to 2 weeks after the first test to watch for this rise.
Infection with other bacteria, such as Yersinia, Francisella, and Vibrio, and immunizations can make the test falsely positive.
Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What Abnormal Results Mean Return to top
If the test detects antibodies, you have likely been exposed to the Brucella bacteria (possible brucellosis).
Risks Return to top
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
Considerations Return to top
A serology test can determine if you have ever been exposed to a particular antigen, but this does not necessarily mean that you are currently infected. Increasing antibody levels are more likely to indicate a current infection.Update Date: 11/1/2007 Updated by: Kenneth M. Wener, M.D., Department of Infectious Diseases, Lahey Clinic, Burlington, MA. Review provided by VeriMed Healthcare Network.