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Alternative Names Return to topDifferential; White blood cell differential count
Definition Return to top
The blood differential test measures the percentage of each type of white blood cell (WBC) that you have in your blood. It also reveals if there are any abnormal or immature cells.
How the Test is Performed Return to top
The health care provider will take blood from your vein. The blood collects into an airtight container.
In infants or a young child, blood will be taken from a heel stick or finger stick. The blood is collected in a small glass tube or onto a slide or test strip.
Cotton or a bandage may be applied to stop any bleeding.
A laboratory specialist takes a drop of blood from your sample and smears it onto a glass slide. The smear is stained with a special dye, which helps tell the difference between various types of white blood cells.
Five types of white blood cells, also called leukocytes, normally appear in the blood:
A computer or the health care provider counts the number of each type of cell. The test shows if the number of cells are in proper proportion with one another, and if there is more or less of one cell type.
How to Prepare for the Test Return to top
No special preparation is necessary.
How the Test Will Feel Return to top
When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the Test is Performed Return to top
This test is done to diagnose an infection, anemia, and leukemia. It may also be used to see if treatment for any of these conditions is working.
Normal Results Return to top
What Abnormal Results Mean Return to top
Any infection or acute stress increases your number of white blood cells. High white blood cell counts may be due to inflammation, an immune response, or blood diseases such as leukemia.
It is important to realize that an abnormal increase in one type of white blood cell can cause a decrease in the percentage of other types of white blood cells.
An increased percentage of neutrophils may be due to:
An increased percentage of lymphocytes may be due to:
A decreased percentage of lymphocytes may be due to:
An increased percentage of monocytes may be due to:
An increased percentage of eosinophils may be due to:
A decreased percentage of basophils may be due to:
Risks Return to top
There is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
References Return to top
Bagby GC. Leukopenia and leukocytosis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 173.Update Date: 2/23/2009 Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.